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Deltacron: New variant or laboratory error?

Deltacron: New variant or laboratory error?

On January 7, scientists in Cyprus reported that they had discovered a new variant of SARS-CoV-2. The variant, named Deltacron, is said to be a hybrid of Delta and Omicron.

The scientists are led by Dr. Leondios Kostrikis, a professor of Biological Sciences at the University of Cyprus.

Dr. Kostrikis reported that the variant has a Delta-like genomeTrusted Source with Omicron characteristics. The team stated that Deltacron had been identified in 25 individuals — some hospitalized and some in the community.

Claims of lab contamination

The identification of Deltacron led to widespread news coverage and much debate on social media, but experts have questioned the findings.

Dr. Jeffrey Barrett, Director of the COVID-19 Genomics Initiative at the Wellcome Sanger Institute in the United Kingdom, believes the findings are due to a lab error.

“This is almost certainly not a biological recombinant of the Delta and Omicron lineages,” he says. “The apparent Omicron mutations are located precisely and exclusively in a section of the sequence encoding the spike gene (amino acids 51 to 143) affected by a technological artifact in certain sequencing procedures.”

Writing on Twitter, Dr. Tom Peacock, a virologist at Imperial College London in the U.K, also dismissed the findings, saying that “[t]he Cypriot ‘Deltacron’ sequences reported by several large media outlets look to be quite clearly contamination.”

In a separate tweet, he nevertheless clarified that this was not due to poor lab practice, stating that it “happens to every sequencing lab occasionally.”

The evolutionary evidence appears to back up their comments. Several experts have stated that if Deltacron was truly a new recombinant variant, samples would cluster on the same branch of SARS-CoV-2’s phylogenetic treeTrusted Source.

However, Deltacron appears randomly on several branches, which experts say is a sure sign of contamination.

Findings defended

However, Dr. Kostrikis defended his findings. He asserted that since Deltacron infection rates were higher in hospitalized patients than in nonhospitalized individuals, the contamination hypothesis was less likely.

In addition, the samples identified as Deltacron were processed in multiple sequencing procedures in more than one country, lessening the likelihood of lab errors, he noted.

The Cyprus team has since reported another 52 cases of Deltacron to the Cyprus Mail. The Cyprus health minister also defended the findings, saying that the groundbreaking research made him “proud of our scientists.”

Call for more evidence

While many experts have dismissed the claims that Deltacron is a new hybrid variant, others are willing to wait for more evidence.

Speaking to Medical News TodayDr. William Schaffner, a professor of infectious diseases at the Vanderbilt University Medical Center, Nashville, TN, commented that “[f]urther local epidemiological investigation in Cyprus is warranted to sort this out. The world certainly is watching.”

“Deltacron has attracted a great deal of interest in the COVID scientific community. Whether it is, indeed, a new variant that has emerged as a result of a combination of Delta and Omicron viruses from a simultaneous infection in a human or whether it happened because of a laboratory accident still remains to be determined.”

– Dr. William Schaffner

Whether that evidence will be forthcoming from Cyprus, or elsewhere, is open to question. MNT contacted Dr. Kostrikis but was still awaiting a response when this article went to press.

Meanwhile, the Cypriot health authorities have stated that the new variant is not one of concern. So, even if Deltacron does exist, what little evidence there is so far suggests we should not be too worried about it.

  • Via Medical News Today

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